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點擊化學 Alkynyl Palmitic Acid

更(geng)新時間:2024-03-14

簡要描述:

點擊化學 Alkynyl Palmitic Acid:
Alkynyl Palmitic Acid 是(shi)一種 PROTAC linker,屬于(yu) alkyl chain 類(lei)。可用于(yu)合成 PROTAC 分子。Alkynyl Palmitic Acid is an alkyl chain-based PROTAC linker that can be used in the synthesis of PR

點擊化學 Alkynyl Palmitic Acid

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炔基(ji)肉豆蔻酸(suan)(suan)(suan)可用(yong)于鑒定和(he)表征翻譯(yi)后的肉豆蔻基(ji)化(hua)蛋白(bai)質(zhi)(zhi) 炔基(ji)棕(zong)(zong)(zong)櫚酸(suan)(suan)(suan)(15-十六烷酸(suan)(suan)(suan)或棕(zong)(zong)(zong)櫚酸(suan)(suan)(suan) (15-yne))是一種修飾的棕(zong)(zong)(zong)櫚酸(suan)(suan)(suan),帶有(you) ω-末端炔烴。 炔基(ji)棕(zong)(zong)(zong)櫚酸(suan)(suan)(suan)通(tong)常(chang)用(yong)于使用(yong)強(qiang)大的點擊化(hua)學識別和(he)表征蛋白(bai)質(zhi)(zhi)的翻譯(yi)后 S-棕(zong)(zong)(zong)櫚酰化(hua)。.

Alkynyl myristic acid is can be used to identify and characterize the post-translational myristylated proteins Alkynyl palmitic acid (15-hexadecynoic acid or Palmitic acid (15-yne)) is a modified palmitic acid with an ω-terminal alkyne. Alkynyl palmitic acid often used to identify and characterize the post-translational S-palmitoylation of proteins using the powerful click chemistry (see References).

結構式 :

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參考文獻

1. Gray, R. A. V., et al. (2021). Optimized Incorporation of Alkynyl Fatty Acid Analogs for the Detection of Fatty Acylated Proteins using Click Chemistry. JoVE Journal, 10 (3791), 62107.

2. Li, B., et al. (2020). TMEM132A, a Novel Wnt Signaling Pathway Regulator Through Wntless (WLS) Interaction. Front Cell Dev Biol., 8, 599890.

3. Lee, M.T., et al. (2020). Dietary sphinganine is selectively assimilated by members of themammaliangut microbiome. J Lipid Res .

4. White, F. K. H., et al. (2019). S-Palmitoylation of junctophilin-2 is critical for its role in tethering the sarcoplasmic reticulum to the plasma membrane. J Biol Chem., 294 (36), 13487-13501.


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